Swiss Catalogue of Learning Objectives for Undergraduate Medical Training

Under a mandate of the Joint Commission of the Swiss Medical Schools

6. Discipline Related Objectives

Pharmacotherapy

Further Knowledge

... interindividual variability and individualized treatment

Objective ID   LevelDTEPG
C PT 1   pharmacological concept: potency of drugs; efficacy; therapeutic index 1
C PT 2   pharmacokinetic parameters in the adult, loading and maintenance doses under normal conditions 2
C PT 3   drug administration routes and pharmaceutical forms 1
C PT 4   therapeutic drug monitoring (indications, modalities, principles of dosing adaptations, timing and blood sampling, detection of incorrect laboratory results) 1
C PT 5   prescribing during pregnancy and breast feeding (safe drugs for common conditions, risks of drugs) 2
C PT 6   prescribing in infancy 1
C PT 7   principles of prescribing in childhood based on body weight and body surface area 2
C PT 8   prescribing in the elderly (pharmacokinetic and dynamic variables and principles of adaptation of dosing) 2
C PT 9   drug-drug interactions (basic pharmacokinetic and pharmacodynamic mechanisms, common drug interactions, use of reference CYP P450 tables) 2
C PT 10   influence on drug metabolism of gender, diet, tobacco and alcohol, naturally occuring and polluting substances (including enzyme induction and inhibition) 1
C PT 11   ways of influences of genomics on pharmacokinetics and pharmacodynamics and its association with interindividual variability in efficacy and toxicity 1
C PT 12   prescribing in renal disease (pharmacokinetic changes, drug dosing, adaptations depending on the creatinine clearance) 2
C PT 13   prescribing in liver disease (pharmacokinetic and pharmacodynamic changes, drugs best avoided, hepatotoxic drugs, estimation of initial and maintenance doses according to hepatic drug clearance) 1
C PT 14   prescribing in heart failure (pharmacokinetic and pharmacodynamic changes, optimal route of drug administration, drugs best avoided in cardiac disease, cardiotoxic drugs, adaptation of initial and maintenance doses in heart failure) 1

... drug safety, prevention and identification of adverse events

Objective ID   LevelDTEPG
C PT 15   adverse drug events (frequency, classification, detection and prevention, risk factors, drug allergy, drug toxicity, importance of toxic drug metabolites, information to patients) 2
C PT 16   definition of pharmacovigilance (causality assessment, reporting) 1
C PT 17   main antidotes in drug poisoning 2
C PT 18   supportive measures in drug poisoning and measures to enhance drug clearance 1
C PT 19   common acute intoxications (sedatives, antidepressants, opiates, opioids, paracetamol, aspirin) 2
C PT 20   drug approval, roles of regulatory (cantonal and federal) authorities 1
C PT 21   prescribing, legal principles 2

... principles of therapeutics

Objective ID   LevelDTEPG
C PT 22   principles for choice of a drug in a class 1
C PT 23   criteria for status as over-the-counter drug 1
C PT 24   self-medication (frequency, symptoms and diseases suitable for, advice to patients) 1
C PT 25   placebo effect (mechanism, importance in clinical research, ethical implications) 2
C PT 26   development of new drugs (preclinical development; phases of clinical trials) 1
C PT 27   pharmacoeconomics: Defined Daily Dose (DDD), pricing and cost effectiveness of drugs 1
C PT 28   pharmaceutical market (industrial, economic, legal and political factors) 1
C PT 29   drug reimbursement (BAG-OFSP drug list) 1
C PT 30   drug efficacy, efficiency and effectiveness, definition of therapeutic progress (based on drug usefulness vs. existing drugs) 1
C PT 31   sources of information on drug treatment 2
C PT 32   drug-marketing (innovative molecule, me-too molecule, new indication for established drug, new formulation, new treatment methods, biased information) 1